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Our top choices for Northwest Alabama hotels

A hotel room with a bed, a desk, a chair, a mirror, a painting, and a nightstand with a lamp.

1. Days Inn by Wyndham Muscle Shoals Florence

Muscle Shoals

Shana

CA $112 total

includes taxes & fees

Nov 10 - Nov 11

An indoor swimming pool with tiled steps and a sunlit room with chairs and a window.

2. Comfort Suites Florence Shoals Area

Florence

Elizabeth

CA $135 total

includes taxes & fees

Nov 29 - Nov 30

A spacious lobby with a reception desk, seating area, and a balcony.

3. Best Western Plus Tuscumbia Muscle Shoals Hotel and Suites

Tuscumbia

Colin

CA $160 total

includes taxes & fees

Nov 15 - Nov 16

A hotel lobby with a seating area, a reception desk, and a check-in counter.

4. Residence Inn Florence Marriott

East Florence

Nathan

CA $197 total

includes taxes & fees

Nov 22 - Nov 23

A hotel room with a bed, a desk with chairs, a small kitchenette, and a TV.

5. Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

Tuscumbia

Zach

CA $99 total

includes taxes & fees

Nov 12 - Nov 13

A modern kitchen with wooden cabinets, a countertop with various appliances, and a view of the outdoors.

6. Holiday Inn Express Hotel & Suites FLORENCE NORTHEAST by IHG

Florence

LaRhonda

CA $171 total

includes taxes & fees

Nov 22 - Nov 23

A snack bar with shelves of snacks and a refrigerator with beverages.

7. Hampton Inn Florence Midtown near University of North Alabama

Florence

calvin

CA $212 total

includes taxes & fees

Nov 15 - Nov 16

A spacious interior with a central staircase, a chandelier, and a view to the outdoors.

8. Spark by Hilton Tuscumbia Muscle Shoals

Tuscumbia

Patrick

CA $131 total

includes taxes & fees

Nov 22 - Nov 23

A restaurant interior with a bar area, seating, and a counter with a coffee machine.

9. The Stricklin Hotel

Florence

Dana

CA $250 total

includes taxes & fees

Nov 10 - Nov 11

A spacious lobby with seating areas, a reception desk, and large windows.

10. Clarion Inn Sheffield Muscle Shoals

Sheffield

Billy

CA $114 total

includes taxes & fees

Nov 15 - Nov 16

A modern living room with a sofa, armchairs, a coffee table, and a TV.

11. Baymont by Wyndham Florence/Muscle Shoals

Florence

Alan

CA $110 total

includes taxes & fees

Nov 22 - Nov 23

A modern bathroom with a freestanding bathtub, a blue chair, and a wooden bench.

12. Comfort Inn & Suites Tuscumbia - Muscle Shoals

Tuscumbia

David

CA $159 total

includes taxes & fees

Dec 9 - Dec 10

A spacious living area with a staircase, a flat-screen TV, and a seating area with a coffee table.

13. Best Western Plus Russellville Hotel & Suites

Russellville

Dennis

CA $168 total

includes taxes & fees

Nov 28 - Nov 29

A hotel with a large pool area, a water tower, and a dome structure.

14. Renaissance Shoals Resort & Spa

East Florence

Christina

CA $437 total

includes taxes & fees

Nov 23 - Nov 24

A modern hotel room with a large bed, a separate sitting area, a bathtub, and a view of the outdoors.

15. Red Roof Inn Muscle Shoals

Muscle Shoals

Keith

CA $92 total

includes taxes & fees

Nov 10 - Nov 11

A reception area with a stone wall, a reception desk, and a door leading outside.

16. Econo Lodge Russellville

Russellville

Mark

CA $109 total

includes taxes & fees

Nov 25 - Nov 26

A spacious lobby with a blue sofa, a wooden table, and chairs. There is a TV on a stand and a painting on the wall.

17. Hampton Inn & Suites Florence-Downtown

Florence

Heather

CA $266 total

includes taxes & fees

Nov 29 - Nov 30

A reception area with a counter, a television, and a door labeled "EMPLOYEES ONLY".

18. Budget Inn & Suites

East Florence

Nazul

CA $93 total

includes taxes & fees

Nov 10 - Nov 11

A reception area with a reception desk, a seating area with chairs and a table, a plant, a lamp, a bulletin board, and a window with a view of the outside.

19. Keywest Inn - Tuscumbia/Muscle Shoals

Tuscumbia

Barbara

CA $118 total

includes taxes & fees

Nov 10 - Nov 11

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, a painting of a sunset, and a bathroom with a mirror and sink.

20. Days Inn by Wyndham Moulton

Moulton

Debra

CA $99 total

includes taxes & fees

Nov 15 - Nov 16

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Vacation Rentals in Northwest Alabama

Cottage

A living room with a ceiling fan, a television, a leather sofa, and a wooden cabinet.

Killen Vacation Rental ~ 4 Mi to Wilson Lake!

Killen

"Great place to stay. "

Cottage

A spacious living area with a dining table, chairs, a TV, and a kitchen area with cabinets and appliances.

A-frame Home ~ 6 Mi to Tennessee River!

Florence

"Cute cottage close to all amenities."

Cottage

A covered patio with wicker furniture, a brick wall, and a view of the garden.

Charming Florence Getaway w/ Fireplace & Grill!

Florence

"The house was beautiful, clean, spacious, and very comfortable. It had all the amenities you could want and need. It was a quiet and nice neighborhood and close to dining and shopping. The owner kept in touch with us the entire stay and was very kind. We will definitely stay there again!"

Cottage

A modern kitchen with granite countertops, a stone backsplash, a built-in oven, and a large window overlooking a garden.

Expansive Florence Home ~ 6 Mi to Downtown!

Florence

"Our family totally loved staying here - close where we needed to be and we were so comfortable - especially with 3 bathrooms for 3 bedrooms! Loved it!"

Cottage

A modern living room with a blue leather sofa, two brown leather armchairs, a small round table, and a staircase leading to the upper floor.

7 Mi to Tennessee River: Home w/ Patio in Florence

Florence

"We loved the place huge rooms we had 10 people and had plenty of room .We would stay again but floors needed sweep and mopped but overall it was a great place ."

Cottage

A sunroom with a glass door, a ceiling fan, a hanging chair, and a view of the lake.

Waterfront Bliss: Wheeler Lake Retreat w/ Dock!

Athens

"Enjoyed your home"

See all vacation rentals

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Stay near popular Northwest Alabama attractions

Dismals Canyon

9.0/10 (35 reviews)

Commune with nature and explore the great outdoors at Dismals Canyon during your travels in Phil Campbell. While you're in the area, wander around the natural setting.

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Learn more about Northwest Alabama

Explore the family-friendly area of Northwest Alabama—live music, entertainment choices, and sights from Dismals Canyon to Cane Creek Canyon Nature Preserve.

See all hotels in Northwest Alabama

A waterfall cascading over rocks in a forested area.

Top Northwest Alabama Hotel Reviews

Microtel Inn & Suites by Wyndham Tuscumbia/Muscle Shoals

10/10 Excellent

"Great price"

Creekside Cabin Getaway - Only 10 Miles from Downtown Florence

10/10 Excellent

"We stayed here and went to our first renaissance fair. The cabin was quiet and clean. Beds were comfortable, kitchen was adequate. The claw foot bath tub was nice after a long day walking. Enjoying coffee and an evening drink on the back porch swing was very relaxing. Just the kind of weekend we needed. Although we had Wi-Fi and Netflix, it felt like we had unplugged. The cabin was close to plenty of good restaurants, and shopping. We will be making another visit next year for certain."